Ausgewählte Publikationen

Long-term trends in mortality and AIDS-defining events after combination ART initiation among children and adolescents with perinatal HIV infectionin 17 middle- and high-income countries in Europe and Thailand: A cohortstudy. European Pregnancy andPaediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord,Judd A, Chappell E, Turkova A, Le Coeur S, Noguera-Julian A, GoetghebuerT, Doerholt K, Galli L, Pajkrt D, Marques L, Collins IJ, Gibb DM,González Tome MI, Navarro M, Warszawski J, Königs C, Spoulou V, Prata F,Chiappini E, Naver L, Giaquinto C, Thorne C, Marczynska M, OkhonskaiaL, Posfay-Barbe K, Ounchanum P, Techakunakorn P, Kiseleva G, Malyuta R,Volokha A, Ene L, Goodall R. PLoS Med.

2018 Jan 30;15(1):e1002491. doi: 10.1371/journal.pmed.1002491. eCollection 2018 Jan.

PMID: 29381702

 

Frequency and epitope specificity of anti-factor VIII C1 domain antibodies in acquired and congenital hemophilia A. Kahle J, Orlowski A, Stichel D, Healey JF, Parker ET, Jacquemin M, Krause M, Tiede A, Schwabe D, Lollar P, Königs C. Blood.

2017 Aug 10;130(6):808-816. doi: 10.1182/blood-2016-11-751347. Epub 2017 May 15.

PMID: 28507083

 

Neurocognitive development in HIV-positive children is correlated with plasma viral loads in early childhood. Weber V, Radeloff D, Reimers B, Salzmann-Manrique E, Bader P, Schwabe D, Königs C. Medicine (Baltimore).

2017 Jun;96(23):e6867. doi: 10.1097/MD.0000000000006867.

PMID: 28591025

 

Developmentof Three Different NK Cell Subpopulations during Immune Reconstitutionafter Pediatric Allogeneic Hematopoietic Stem Cell Transplantation:Prognostic Markers in GvHD and Viral Infections. HueneckeS, Cappel C, Esser R, Pfirrmann V, Salzmann-Manrique E, Betz S, KeitlE, Banisharif-Dehkordi J, Bakhtiar S, Königs C, Jarisch A, Soerensen J,Ullrich E, Klingebiel T, Bader P, Bremm M.

Front Immunol. 2017 Feb 10;8:109. doi: 10.3389/fimmu.2017.00109. eCollection 2017.

PMID: 28239380

 

Rare genetic variants in SMAP1, B3GAT2, and RIMS1 contribute to pediatric venous thromboembolism. RühleF, Witten A, Barysenka A, Huge A, Arning A, Heller C, Krümpel A,Mesters R, Franke A, Lieb W, Riemenschneider M, Hiersche M, Limperger V,Nowak-Göttl U, Stoll M.

Blood. 2017 Feb 9;129(6):783-790. doi: 10.1182/blood-2016-07-728840. Epub 2016 Dec 23.

PMID: 28011674

 

FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII. Yoon J, Schmidt A, Zhang AH, Königs C, Kim YC, Scott DW.

Blood. 2017 Jan 12;129(2):238-245. doi: 10.1182/blood-2016-07-727834. Epub 2016 Nov 15.

PMID: 28064157

 

Impactof high risk thrombophilia status on recurrence among children andadults with VTE: An observational multicenter cohort study. BrüwerG, Limperger V, Kenet G, Klostermeier UC, Shneyder M, Degenhardt F,Finckh U, Heller C, Holzhauer S, Trappe R, Kentouche K, Knoefler R,Kurnik K, Krümpel A, Lauten M, Manner D, Mesters R, Junker R,Nowak-Göttl U.

Blood Cells Mol Dis. 2016 Nov;62:24-31. doi: 10.1016/j.bcmd.2016.10.024. Epub 2016 Nov 5.

PMID: 27838551

 

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors. Batsuli G, Deng W, Healey JF, Parker ET, Baldwin WH, Cox C, Nguyen B, Kahle J, Königs C, Li R, Lollar P, Meeks SL.

Blood. 2016 Oct 20;128(16):2055-2067. doi: 10.1182/blood-2016-02-701805. Epub 2016 Jul 5.

PMID: 27381905

 

High seroprevalence of antibodies against Kaposi's sarcoma-associatedherpesvirus (KSHV) among HIV-1-infected children and adolescents in anon-endemic population. Feiterna-SperlingC, Königs C, Notheis G, Buchholz B, Krüger R, Weizsäcker K, Eberle J,Hanhoff N, Gärtner B, Heider H, Krüger DH, Hofmann J.

Med Microbiol Immunol. 2016 Oct;205(5):425-34. doi: 10.1007/s00430-016-0458-x. Epub 2016 May 30.

PMID: 27240652

 

Impactof high-risk thrombophilia status on recurrence among children with a first non-central-venous-catheter-associated VTE: an observationalmulticentre cohort study. LimpergerV, Kenet G, Goldenberg NA, Heller C, Holzhauer S, Junker R,Klostermeier UC, Knoefler R, Kurnik K, Krümpel A, Mesters R, Stach M,Young G, Nowak-Göttl U.

Br J Haematol. 2016 Oct;175(1):133-40. doi: 10.1111/bjh.14192. Epub 2016 Jun 22.

PMID: 27329967

 

Contemporary issues in the management of von Willebrand disease. Federici AB, Königs C, James AH.

Thromb Haemost. 2016 Aug 31;116 Suppl 1:S18-25. doi: 10.1160/TH16-01-0050. Epub 2016 Aug 16.

PMID: 27528278

 

Neutralisation of factor VIII inhibitors by anti-idiotypes isolated from phage-displayed libraries. Schmidt A, Brettschneider K, Kahle J, Orlowski A, Becker-Peters K, Stichel D, Schulze J, Braner M, Tampé R, Schwabe D, Königs C.

Thromb Haemost. 2016 Jul 4;116(1):32-41. doi: 10.1160/TH15-12-0925. Epub 2016 Mar 24.

PMID: 27009573

 

Nevirapine extended-release formulation tablets in HIV-1-infected children--long-term follow-up. Anabwani G, Königs C, Giaquinto C, Aslanyan S, Sabo JP, Morrow JS, Feiterna-Sperling C.

Clin Infect Dis. 2015 Aug 1;61(3):476-9. doi: 10.1093/cid/civ340. Epub 2015 Apr 26.

PMID: 25917636

 

Epitope mapping via selection of anti-FVIII antibody-specific phage-presented peptide ligands that mimic the antibody binding sites. Kahle J, Orlowski A, Stichel D, Becker-Peters K, Kabiri A, Healey JF, Brettschneider K, Naumann A, Scherger AK, Lollar P, Schwabe D,Königs C1.

Thromb Haemost. 2015 Feb;113(2):396-405. doi: 10.1160/TH14-01-0101. Epub 2014 Dec 18

 

German cohort of HCV mono-infected and HCV/HIV co-infected patients reveals relative under-treatment of co-infected patients. Beisel C, Heuer M, Otto B, Jochum J, Schmiedel S, Hertling S, Degen O, Lüth S, van Lunzen J, Schulze Zur Wiesch J.

AIDS Res Ther. 2014 Jul 1;11:16

 

Steady-state pharmacokinetics of nevirapine extended-release tablets in HIV-1-infected children and adolescents: an open-label, multiple-dose, cross-over study. Giaquinto C, Anabwani G, Feiterna-Sperling C, Nuttall J, Mompati K, Königs C, Mensa FJ, Sabo JP, Yong CL, MacGregor TR, Nguyen T, Quinson AM.

Pediatr Infect Dis J. 2014 Jul;33(7):e173-9

 

Pharmacokinetics of pediatric lopinavir/ritonavir tablets in children when administered twice daily according to FDA weight bands. Bastiaans DE, Forcat S, Lyall H, Cressey TR, Hansudewechakul R, Kanjanavanit S, Noguera-Julian A, Königs C, Inshaw JR, Chalermpantmetagul S, Saïdi Y, Compagnucci A, Harper LM, Giaquinto C, Colbers AP, Burger DM; PENTA 18KONCERT Study Group.

Pediatr Infect Dis J. 2014 Mar;33(3):301-5

 

Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations. Ungerer C, Quade-Lyssy P, Radeke HH, Henschler R, Königs C, Köhl U, Seifried E, Schüttrumpf J.

Stem Cells Dev. 2014 Apr 1;23(7):755-66

 

Clinical and laboratory characteristics of children with venous thromboembolism and protein C-deficiency: an observational Israeli-German cohort study. Limperger V, Klostermeier UC, Kenet G, Holzhauer S, Alhenc Gelas M, Finckh U, Junker R, Heller C, Zieger B, Kurnik K, Knöfler R, Mesters R, Halimeh S, Nowak-Göttl U.

Br J Haematol. 2014 Nov;167(3):385-93

 

Beriate® P in the treatment of patients with haemophilia A: Results of a long-term pharmacovigilance study. Klamroth R, Holzhauer S, Zimmermann R, Heller C, Kurnik K; for the Beriate(®) Pharmacovigilance Group.

Thromb Res. 2014 Jan 10. pii: S0049-3848(13)00484-2

 

Selection and characterisation of FVIII-specific single chain variable fragments. Naumann A, Scherger AK, Neuwirth J, Orlowski A, Kahle J, Schwabe D, Königs C.

Hamostaseologie. 2013 Oct 30;33 Suppl 1:S39-45.

Risk factors for high-titer inhibitor development in children with hemophilia a: results of a cohort study. Halimeh S, Bidlingmaier C, Heller C, Gutsche S, Holzhauer S, Kenet G, Kurnik K, Manner D, Iorio A, Nowak-Göttl U.

Biomed Res Int. 2013;2013:901975. Epub 2013 Oct 2.

 

Risk of angioedema following invasive or surgical procedures in HAE type I and II - the natural history. Aygören-Pürsün E, Martinez Saguer I, Kreuz W, Klingebiel T, Schwabe D.

Allergy. 2013 Aug;68(8):1034-9.

 

Age-matched dendritic cell subpopulations reference values in childhood. Heinze A, Elze MC, Kloess S, Ciocarlie O, Königs C, Betz S, Bremm M, Esser R, Klingebiel T, Serban M, Hutton JL, Koehl U.

Scand J Immunol. 2013 Mar;77(3):213-20.

 

Comparison of three humanized mouse models for adoptive T cell transfer. Volk A, Hartmann S, Muik A, Geiss Y, Königs C, Dietrich U, von Laer D, Kimpel J.

J Gene Med. 2012 Aug;14(8):540-8.

 

Inherited thrombophilia in children with venous thromboembolism and the familial risk of thromboembolism: an observational study. Holzhauer S, Goldenberg NA, Junker R, Heller C, Stoll M, Manner D, Mesters R, Krümpel A, Stach M, Nowak-Göttl U.

Blood. 2012 Aug 16;120(7):1510-5.

 

Guideline for antiretroviral therapy of HIV-infected children and adolescents. Neubert J, Niehues T, Baumann U, Buchholz B, Notheis G, Wintergerst U, Blume J, Feiterna-Sperling C, Laws HJ, Linde R, Königs C.

Pädiatrische Arbeitsgemeinschaft AIDS (PAAD). Klin Padiatr. 2012 Mar;224(2):98-110.

 

Pharmacokinetics and short-term safety and tolerability of etravirine in treatment-experienced HIV-1-infected children and adolescents. Königs C, Feiterna-Sperling C, Esposito S, Viscoli C, Rosso R, Kakuda TN, Leemans R, Peeters M, Mack R, Peeters I, Sinha R, Boven K, Giaquinto C.

AIDS. 2012 Feb 20;26(4):447-55.

 

 

Home therapy with intravenous human C1-inhibitor in children and adolescents with hereditary angioedema. Kreuz W, Rusicke E, Martinez-Saguer I, Aygören-Pürsün E, Heller C, Klingebiel T.

Transfusion. 2012 Jan;52(1):100-7.

 

Secreted antiviral entry inhibitory (SAVE) peptides for gene therapy of HIV infection. Egerer L, Volk A, Kahle J, Kimpel J, Brauer F, Hermann FG, von Laer D.

Mol Ther. 2011 Jul;19(7):1236-44.

 

Molecular basis of antithrombin deficiency. Luxembourg B, Delev D, Geisen C, Spannagl M, Krause M, Miesbach W, Heller C, Bergmann F, Schmeink U, Grossmann R, Lindhoff-Last E, Seifried E, Oldenburg J, Pavlova A.

Thromb Haemost. 2011 Apr;105(4):635-46.

 

Peptide ligands selected with CD4-induced epitopes on native dualtropic HIV-1 envelope proteins mimic extracellular coreceptor domains and bind to HIV-1 gp120 independently of coreceptor usage. Dervillez X, Klaukien V, Dürr R, Koch J, Kreutz A, Haarmann T, Stoll M, Lee D, Carlomagno T, Schnierle B, Möbius K, Königs C, Griesinger C, Dietrich U.

J Virol. 2010 Oct;84(19):10131-8.

 

Characterization of acute hereditary angioedema attacks during pregnancy and breast-feeding and their treatment with C1 inhibitor concentrate. Martinez-Saguer I, Rusicke E, Aygören-Pürsün E, Heller C, Klingebiel T, Kreuz W.

Am J Obstet Gynecol. 2010 Aug;203(2):131.e1-7.

 

Validation of a predictive model for identifying an increased risk for thromboembolism in children with acute lymphoblastic leukemia: results of a multicenter cohort study. Mitchell L, Lambers M, Flege S, Kenet G, Li-Thiao-Te V, Holzhauer S, Bidlingmaier C, Frühwald MC, Heller C, Schmidt W, Pautard B, Nowak-Göttl U.

Blood. 2010 Jun 17;115(24):4999-5004.

 

HIV-infection in children and adolescents. Baumann U, Buchholz B, Königs C.

MMW Fortschr Med. 2010 Apr 29;152(17):40-1, 43-4.

 

Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. Kenet G, Lütkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, Chabrier S, Chan A, deVeber G, Fiedler B, Fullerton HJ, Goldenberg NA, Grabowski E, Günther G, Heller C, Holzhauer S, Iorio A, Journeycake J, Junker R, Kirkham FJ, Kurnik K, Lynch JK, Male C, Manco-Johnson M, Mesters R, Monagle P, van Ommen CH, Raffini L, Rostásy K, Simioni P, Sträter RD, Young G, Nowak-Göttl U.

Circulation. 2010 Apr 27;121(16):1838-47. Review.

 

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Stein S, Ott MG, Schultze-Strasser S, Jauch A, Burwinkel B, Kinner A, Schmidt M, Krämer A, Schwäble J, Glimm H, Koehl U, Preiss C, Ball C, Martin H, Göhring G, Schwarzwaelder K, Hofmann WK, Karakaya K, Tchatchou S, Yang R, Reinecke P, Kühlcke K, Schlegelberger B, Thrasher AJ, Hoelzer D, Seger R, von Kalle C, Grez M.

Nat Med. 2010 Feb;16(2):198-204.

 

PENTA 2009 guidelines for the use of antiretroviral therapy in paediatric HIV-1 infection. PENTA Steering Committee, Welch S, Sharland M, Lyall EG, Tudor-Williams G, Niehues T, Wintergerst U, Bunupuradah T, Hainaut M, Della Negra M, Pena MJ, Amador JT, Gattinara GC, Compagnucci A, Faye A, Giaquinto C, Gibb DM, Gandhi K, Forcat S, Buckberry K, Harper L, Königs C, Patel D, Bastiaans D.

HIV Med. 2009 Nov;10(10):591-613.

 

C1-inhibitor concentrate for individual replacement therapy in patients with severe hereditary angioedema refractory to danazol prophylaxis. Kreuz W, Martinez-Saguer I, Aygören-Pürsün E, Rusicke E, Heller C, Klingebiel T.

Transfusion. 2009 Sep;49(9):1987-95.

 

A review of current literature on second-generation, sucrose-formulated, full-length recombinant factor VIII. Königs C, von Hentig N.

Drugs Today (Barc). 2009 Jul;45(7):549-61. Review.

 

Multimerization of peptide mimotopes for blocking of factor VIII neutralizing antibodies. Kessel C, Kreuz W, Klich K, Becker-Peters K, Vorpahl F, Dietrich U, Klingebiel T, Königs C.

ChemMedChem. 2009 Aug;4(8):1364-70.

 

Short communication: Different mutation patterns in subtype CRF06_cpx after mother-to-child transmission. Stürmer M, Carlebach A, Staszewski S, Linde R, Königs C, Doerr HW, Däumer M, Berger A.

AIDS Res Hum Retroviruses. 2008 Nov;24(11):1429-33.

 

Humoral immune responsiveness to a defined epitope on factor VIII before and after B cell ablation with rituximab. Kessel C, Königs C, Linde R, Escuriola-Ettinghausen C, Stoll H, Klingebiel T, Dietrich U, Kreuz W.

Mol Immunol. 2008 Nov;46(1):8-15.

 

Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies. Young G, Albisetti M, Bonduel M, Brandao L, Chan A, Friedrichs F, Goldenberg NA, Grabowski E, Heller C, Journeycake J, Kenet G, Krümpel A, Kurnik K, Lubetsky A, Male C, Manco-Johnson M, Mathew P, Monagle P, van Ommen H, Simioni P, Svirin P, Tormene D, Nowak-Göttl U. Circulation.

2008 Sep 23;118(13):1373-82. Review.

 

Peptide mimotopes selected with HIV-1-blocking monoclonal antibodies against CCR5 represent motifs specific for HIV-1 entry. Königs C, Pustowka A, Irving J, Kessel C, Klich K, Wegner V, Rowley MJ, Mackay IR, Kreuz W, Griesinger C, Dietrich U.

Immunol Cell Biol. 2007 Oct;85(7):511-7.

 

Risk factors for recurrent venous thromboembolism in the European collaborative paediatric database on cerebral venous thrombosis: a multicentre cohort study. Kenet G, Kirkham F, Niederstadt T, Heinecke A, Saunders D, Stoll M, Brenner B, Bidlingmaier C, Heller C, Knöfler R, Schobess R, Zieger B, Sébire G, Nowak-Göttl U;

European Thromboses Study Group. Lancet Neurol. 2007 Jul;6(7):595-603.

 

Effect of first line therapy including efavirenz and two nucleoside reverse transcriptase inhibitors in HIV-infected children. Funk MB, Notheis G, Schuster T, Elanjkal Z, von Hentig N, Stürmer M, Linde R, Dunsch D, Königs C, Wintergerst U, Kreuz W.

Eur J Med Res. 2005 Dec 7;10(12):503-8.

 

Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5. O'Connor KH, Königs C, Rowley MJ, Irving JA, Wijeyewickrema LC, Pustowka A, Dietrich U, Mackay IR.

J Immunol Methods. 2005 Apr;299(1-2):21-35.

 

Thrombosis in children with hematologic malignancies. Schobess R, Kempf-Bielack B, Schwabe D, Sträter R, Nowak-Göttl U.

Rev Clin Exp Hematol. 2004 Jun 1;8(1):E2. Review.

 

Central nervous system imaging in childhood leukaemia. Porto L, Kieslich M, Schwabe D, Zanella FE, Lanfermann H.

Eur J Cancer. 2004 Sep;40(14):2082-90.

 

Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-up. Kosch A, Kuwertz-Bröking E, Heller C, Kurnik K, Schobess R, Nowak-Göttl U.

Blood. 2004 Sep 1;104(5):1356-60.

 

Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in children. Kosch A, Koch HG, Heinecke A, Kurnik K, Heller C, Nowak-Göttl U.

Childhood Thrombophilia Study Group. Thromb Haemost. 2004 Feb;91(2):308-14.

 

Recurrent thromboembolism in infants and children suffering from symptomatic neonatal arterial stroke: a prospective follow-up study. Kurnik K, Kosch A, Sträter R, Schobess R, Heller C, Nowak-Göttl U.

Childhood Stroke Study Group. Stroke. 2003 Dec;34(12):2887-92.

 

Identification of peptide ligands for target RNA structures derived from the HIV-1 packaging signal psi by screening phage-displayed peptide libraries. Pustowka A, Dietz J, Ferner J, Baumann M, Landersz M, Königs C, Schwalbe H, Dietrich U.

Chembiochem. 2003 Oct 6;4(10):1093-7.

 

Cerebral venous thrombosis in children: a multifactorial origin. Heller C, Heinecke A, Junker R, Knöfler R, Kosch A, Kurnik K, Schobess R, von Eckardstein A, Sträter R, Zieger B, Nowak-Göttl U.

Childhood Stroke Study Group. Circulation. 2003 Sep 16;108(11):1362-7.

 

Epidemiology of inhibitors and current treatment strategies. Kreuz W, Ettingshausen CE, Auerswald G, Saguer IM, Becker S, Funk M, Heller C, Klarmann D, Klingebiel T.

GTH PUP Study Group. Haematologica. 2003 Jun;88(6):EREP04. Review.

 

Cerebrovascular complications of L-asparaginase in the therapy of acute lymphoblastic leukemia. Kieslich M, Porto L, Lanfermann H, Jacobi G, Schwabe D, Böhles H.

J Pediatr Hematol Oncol. 2003 Jun;25(6):484-7.

 

Maternal thrombophilia and neonatal thrombosis. Heller C, Nowak-Göttl U.

Best Pract Res Clin Haematol. 2003 Jun;16(2):333-45. Review.

 

Thromboembolic events in children with acute lymphoblastic leukemia (BFM protocols): prednisone versus dexamethasone administration. Nowak-Göttl U, Ahlke E, Fleischhack G, Schwabe D, Schobess R, Schumann C, Junker R.

Blood. 2003 Apr 1;101(7):2529-33.

 

First manifestation of a hereditary homozygous factor VII deficiency in a 3-year-old girl suspected as purpura fulminans. Fischer D, Veldman A, Heller C, Kreuz W, Schneider W.

Intensive Care Med. 2003 Jan;29(1):144.

 

Elevated lipoprotein(a) concentration is an independent risk factor of venous thromboembolism. Nowak-Göttl U, Schobess R, Kurnik K, Schwabe D, Fleischhack G, Junker R.

Blood. 2002 May 1;99(9):3476-7;

 

Analysis of cellular factors influencing the replication of human immunodeficiency virus type I in human macrophages derived from blood of different healthy donors. Eisert V, Kreutz M, Becker K, Königs C, Alex U, Rübsamen-Waigmann H, Andreesen R, von Briesen H.

Virology. 2001 Jul 20;286(1):31-44.

 

Monoclonal antibody screening of a phage-displayed random peptide library reveals mimotopes of chemokine receptor CCR5: implications for the tertiary structure of the receptor and for an N-terminal binding site for HIV-1 gp120. Königs C, Rowley MJ, Thompson P, Myers MA, Scealy M, Davies JM, Wu L, Dietrich U, Mackay CR, Mackay IR.

Eur J Immunol. 2000 Apr;30(4):1162-71.

 

Cerebral venous sinus thrombosis in children with acute lymphoblastic leukemia carrying the MTHFR TT677 genotype and further prothrombotic risk factors. Wermes C, Fleischhack G, Junker R, Schobess R, Schwabe D, Sykora KW, Nowak-Göttl U.

Klin Padiatr. 1999 Jul-Aug;211(4):211-4.

 

Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors. Nowak-Göttl U, Wermes C, Junker R, Koch HG, Schobess R, Fleischhack G, Schwabe D, Ehrenforth S.

Blood. 1999 Mar 1;93(5):1595-9.